|
KMID : 0352519820190030745
|
|
Korea Univercity Medical Journal
1982 Volume.19 No. 3 p.745 ~ p.757
|
|
|
A Study on Carcino-embryonic Antigen(CEA) in the Serum and Tissue of Patients with Various Diseases
|
|
李賢淑/Lee, Hyun-Sook
金仁仙/白承龍/Kim, In-Sun/Paik, Seung-Yong
|
|
|
Abstract
|
|
|
Carcino-embryonic antigen is a tumor-associated antigen whose testing has been considered to have a significant value in monitoring the patients with a variety of cancers.
However, all the patients with malignant tumors do not reveal the elevation of serum CEA. Thus, to evaluate the relationship between serum and tissue CEA concentration, the author has studied serum CEA levels in 76 malignant and 89 nonmalignant diseases and demonstrated tissue CEA in 47 malignant and 13 nonmalignant diseases, using formalin-fixed, paraffin-embedded tissues and immunoperoxidase technique.
The results obtained are as follows:
1. The positivity in patients with malignant diseases was 895vo in pancreatic, 80%, in pulmonary, 67% in hepatic, 64% in colorectal, 64% in gastric and 25% in genitourinary cancers.
2. The positivity in patients with nonmalignant diseases was 53% in gastrointestinal, 63% in hepatobiliary and pancreatic, 69%, in pulmonary, 27% in genitourinary tract, 67% in cardiac and 67% in miscellaneous diseases.
3. The positivity of serum CEA in patients with gastric, colorectal and pancreatic cancers was dependent upon the extent of the diseases process.
4. The positive staining for CEA in the tissues of malignant diseases was 81%, as a whole; the staining was high in gastric, colorectal and pancreatic cancers but was low in genitourinary tract cancer, revealing correlation with the degree of staining and tumor differentiation.
5. The positive staining for CEA in the tissues of nonmalignant diseases was 54%, but the degree of staining was weak.
6. Most of the cases, the negative staining for CEA, had serum CEA levels less than 5.ong/ml; whereas there was no constant relationship between-serum CEA levels and the
degree of staining for CEA in tissues.
To be brief, the findings suggested that the estimation of the serum CEA levels would be useful to aid in the diagnosis of a variety of cancers and evaluate the extent of the disease process. Also the immunohistochemical identification of CEA in tissue sections might have histopatholegical diagnostic implications and provide a solid basis for use of CEA in the follow-up mar_agement of cancer patients.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|
|